Journal: Scientific Reports

Article Title: Responsive deep brain stimulation for the treatment of Tourette syndrome

doi: 10.1038/s41598-024-57071-5

Figure Lengend Snippet: Tourette DBS cohort characteristics.

Article Snippet: Our first proof of concept for a responsive DBS device in TS was deployed in a single subject (2017) with a different device than used the current study (Neuropace, Mountainview, CA) .

Techniques:

Journal: Scientific Reports

Article Title: Responsive deep brain stimulation for the treatment of Tourette syndrome

doi: 10.1038/s41598-024-57071-5

Figure Lengend Snippet: Physiology features for responsive deep brain stimulation and programming ramp dynamics. The electrophysiology represent the average spectrograms of the individual signals from each subject. X axis is time (seconds) and y axis is frequency (Hz). Tic onset is denoted by the arrow and black vertical line The feature used was the feature selected for responsive stimulation trials and the ramp on and off time were the values used to program the DBS device in responsive mode.

Article Snippet: Our first proof of concept for a responsive DBS device in TS was deployed in a single subject (2017) with a different device than used the current study (Neuropace, Mountainview, CA) .

Techniques:

Journal: Toxicology in Vitro

Article Title: From in vitro to in vivo: Integration of the virtual cell based assay with physiologically based kinetic modelling

doi: 10.1016/j.tiv.2017.06.015

Figure Lengend Snippet: KNIME workflow to perform IVIVE, for human exposure, based on the estragole PBD model.

Article Snippet: Estragole dose response predictions using the automated human estragole PBK/D model to perform IVIVE (KNIME workflow), readouts for A.

Techniques:

Journal: Toxicology in Vitro

Article Title: From in vitro to in vivo: Integration of the virtual cell based assay with physiologically based kinetic modelling

doi: 10.1016/j.tiv.2017.06.015

Figure Lengend Snippet: Estragole dose response predictions using the automated human estragole PBK/D model to perform IVIVE (KNIME workflow), readouts for A. Cell viability (viability is normalized to 1, with no concentration of estragole 100% of the cell as viable) and B. DNA adducts (Y-axis in adducts/10^8 nucleotide).

Article Snippet: Estragole dose response predictions using the automated human estragole PBK/D model to perform IVIVE (KNIME workflow), readouts for A.

Techniques: Concentration Assay

Journal: bioRxiv

Article Title: Micro and nanoplastic inhalation during pregnancy elicits uterine endothelial dysfunction in Sprague Dawley rats by impeding nitric oxide signaling

doi: 10.1101/2025.09.12.675811

Figure Lengend Snippet: Vascular reactivity of the uterine artery was assessed via wire myography. Concentration-response curves were generated after treatment of uterine artery segments with increasing concentrations of the endothelial-dependent vasodilator methacholine (A), the endothelial-independent vasodilator sodium nitroprusside (B), and the vasoconstrictor phenylephrine (C). Significance was assessed by comparing overall reactivity via a four-parameter nonlinear regression analysis. Data are presented as mean ± SEM, n =7-10.

Article Snippet: Endothelium-dependent relaxation, endothelium-independent relaxation, and smooth muscle contraction were separately evaluated via cumulative additions of 60 μL of Methacholine chloride (MCh, MP Biomedicals, CAT 190231), Sodium Nitroprusside Dihydrate (SNP, Sigma-Aldrich, CAT 567538), and Phenylephrine (PE, Thermofisher Scientific, CAT 207240100), respectively for a concentration-response curve spanning from 10 − 9 to 10 − 4 M for each pharmacological application.

Techniques: Concentration Assay, Generated

Journal: bioRxiv

Article Title: Micro and nanoplastic inhalation during pregnancy elicits uterine endothelial dysfunction in Sprague Dawley rats by impeding nitric oxide signaling

doi: 10.1101/2025.09.12.675811

Figure Lengend Snippet: Vascular reactivity of the radial artery was assessed via pressure myography. Concentration-response curves were generated after treatment of radial artery segments with increasing concentrations of the endothelial-dependent vasodilator methacholine (A), the endothelial-independent vasodilator sodium nitroprusside (B), and the vasoconstrictor phenylephrine (C). Significance was assessed by comparing overall reactivity via a four-parameter nonlinear regression analysis. Data are presented as mean ± SEM, n =8-10. Significant differences (p < 0.05) from the control group are denoted by * and significant differences from the polyamide-exposed group are denoted by †.

Article Snippet: Endothelium-dependent relaxation, endothelium-independent relaxation, and smooth muscle contraction were separately evaluated via cumulative additions of 60 μL of Methacholine chloride (MCh, MP Biomedicals, CAT 190231), Sodium Nitroprusside Dihydrate (SNP, Sigma-Aldrich, CAT 567538), and Phenylephrine (PE, Thermofisher Scientific, CAT 207240100), respectively for a concentration-response curve spanning from 10 − 9 to 10 − 4 M for each pharmacological application.

Techniques: Concentration Assay, Generated, Control